Health Research and Policy

Abstract

DATE: January 17, 2013
TIME: 1:15 - 3:00 pm
LOCATION: Medical School Office Building, Rm x303
TITLE: The Kaiser Permanente/UCSF Genetic Research Study on Adult Health and Aging: Genome-wide association study in a cohort of 100,000
SPEAKER: Thomas Hoffmann, Assistant Professor, UCSF

The Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort contains extensive longitudinal, prescription medication, and genotypes at over 650,000 markers for nearly all of it's 100,000 participants, composed of 81% White, 7.5% Asian, 7% Latino, and 3.5% African American race/ethnicities. Here we describe the cohort, give a background how the genotype arrays were designed, and give preliminary analysis results of approximately 1 million longitudinal lipid measurement values linked to individuals from electronic medical records. We discovered 28 novel lipid loci. These results demonstrate the remarkable power of this cohort for identifying genes underlying complex traits using high-quality longitudinal electronic health records linked to extensive GWAS data.

Suggested readings:
General GWAS introduction: http://www.nature.com/nrg/journal/v9/n5/full/nrg2344.html

Paper describing the array design: http://www.jstor.org/stable/2532911

Stanford Medicine Resources:

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