Health Research and Policy

Abstract

DATE: November 7, 2013
TIME: 1:15 - 3:00 pm
LOCATION: Medical School Office Building, Rm x303
TITLE: Identity by Descent in Population Data
SPEAKER: Sharon Browning
Research Associate Professor, Dept of Biostatistics, University of Washington

We and others have recently developed statistical methods for detecting short segments of identity by descent (IBD) between individuals with no known relationship using genome-wide genetic data. The detected IBD segments have many uses including finding genetic associations, estimating heritability, and estimating genotype error rates. I will describe the principles behind methods for IBD segment detection and show methods and results for these applications.

Suggested readings:
Browning, S. R. and B. L. Browning, 2012. Identity by Descent Between Distant Relatives: Detection and Applications. Annual Review of Genetics, 46: 617-633.

Thompson, E. A., 2013. Identity by Descent: Variation in Meiosis, Across Genomes, and in Populations. Genetics, 194:301-326.

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