Health Research and Policy

Abstract

DATE: February 14, 2013
TIME: 1:15 - 3:00 pm
LOCATION: Medical School Office Building, Rm x303
TITLE: Molecular Imaging in Medicine: Current Standards and Challenges
SPEAKER: Dr. Jesse Jokerst
Postdoctoral Fellow, Gambhir Lab, Dept of Radiology, Stanford

Molecular imaging creates real time visual representations of complex biochemical processes involved in normal physiology and disease states in living cells, tissues, and intact subjects. Working at the interface of chemistry, biology, physics, mathematics, and medicine, molecular imaging researchers are developing new ways to approach diagnostics, drug design, and therapy. In this lecture I will define molecular imaging and contrast it with traditional Radiology. I will then describe the key components of a molecular imaging experiment including synthesis of contrast agents, data collection/validation, and image interpretation—this workflow will be supplemented with several case studies to highlight the findings possible with molecular imaging. We will close with some statistical problems facing molecular imaging researchers including best practices in Region of Interest (ROI) analysis.

Suggested reading:
F. Habte, S. Budhiraja, S. Keren, T.C. Doyle, C.S. Levin, D. Paik. In situ Study of the Impact of Inter- and Intra-reader Variability on Region of Interest (ROI) Analysis in Preclinical Molecular Imaging

Michelle L. James and Sanjiv S. Gambhir. A molecular imaging primer: modalities, imaging agents, and applications. Physio Rev 92: 897-965, 2012.

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