Health Research and Policy


DATE: November 15, 2012
TIME: 1:15 - 3:00 pm
LOCATION: Li Ka Shing Center for Learning (LKSC)
291 Campus Dr, Room LK 209
1:15 pm - 3:00 pm
TITLE: Understanding Cancer Drug Sensitivity
SPEAKER: Dr David A. Knowles
Post Doctoral Scholar, Computer Science, Stanford

Various recent studies have involved measuring the sensitivity of an array of cancer cell lines to a set of anti-cancer drugs. To date, only very simple questions have been asked of this data: for example, what genes are correlated with sensitivity to a particular drug? The clinically interesting question is: given limited characteristics of a tumour, can we predict which drugs will mostly effectively inhibit its growth? From a basic biology perspective, can the observed sensitivity patterns help us understand what regulatory mechanisms are broken in a particular cell line?

Suggested readings:
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, J Barretina et al. - Nature, 2012

Integrated analysis of breast cancer cell lines reveals unique signaling pathways, LM Heiser et al. - Genome, 2009

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