Technology Development and Translational Research
Translational Research Program
Advances in our knowledge of basic biology, together with a rapid increase in our understanding of molecular genetics, are providing unprecedented opportunities to develop new approaches to the diagnosis and treatment of human disease. As part of the Beckman Center’s emphasis on translational medicine, the PMGM established the Interdisciplinary Translational Research Seed Grant Program.
Stimulating Collaborations across Multiple Disciplines
The primary goal of the seed grant program is to stimulate collaborations across multiple disciplines and forge a meaningful interface between the basic, applied, and clinical sciences so that laboratory research and discovery can be “translated” into new diagnostic and therapeutic applications. The program also seeks to engage trainees—medical students, graduate students, clinical fellows, and postdoctoral fellows—in groundbreaking collaborative research. Projects funded under this program represent innovation in a broad array of scientific disciplines, with teams composed of two or more researchers, including a combination of physician-investigators, basic scientists, applied scientists, and trainees.
Translational research seed grant projects have resulted in promising outcomes that include significant research data, published papers, grant and patent applications, and media coverage.
The seed grant program stimulates collaborations across disciplines so that research discoveries can be translated into therapeutic applications.
In order to help initiate innovative new translational research projects, the Beckman Center for Molecular and Genetic Medicine conducts a highly competitive technology development granting program, in which pairs of investigators representing different disciplines propose risky but high-pay-off experiments in technology innovation.
PMGM advisory committee members evaluate the proposals and the Center provides $100,000 a year (for projects of two years’ duration) to the best proposals. This program has been highly successful and has leveraged funding from both federal and private sources for many of the seeded proposals.
Seed Grants Awarded, By Year
- A next-generation imaging technology for human tissue atlases. Pehr Harbury, PhD, Department of Biochemistry; Tushar Desai, MD, Department of Internal Medicine
- Developing FFPE-optimized CODEX to reveal the cutaneous T cell lymphoma tumor microenvironment in response to immunotherapy. Garry Nolan, PhD, Department of Microbiology and Immunology; Youn Kim, MD, Department of Dermatology
- Optical tools to assess neuronal function in human stem cell-based disease models. Marius Wernig, MD, PhD, Department of Pathology (Stem Cell Institute); Alice Ting, PhD, Departments of Genetics and Biology
- Scalable long-term DNA storage with error correction and random-access retrieval. Tsachy Weissman, PhD, Department of Electrical Engineering; Hanlee Ji, MD, Department of Medicine (Oncology)
- Targeting the influenza matrix layer through hyper-stabilization. Karla Kirkegaard, PhD, Department of Genetics; Wah Chiu, PhD, Department of Bioengineering