Research Team

Principle Investigator

Justin P. Annes MD PhD

Thank you for visiting us and learning about our exciting work!   

Everyday in lab is an adventure- learning basic biologic mechanisms, discovering new therapeutic targets and synthesizing novel compounds that will one day (hopefully) become medicines. Important work that's fun to do.   

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Dr. Annes is an Associate Professor of Medicine at Stanford University in the Division of Endocrinology. Justin was previously an Instructor in Medicine at Harvard Medical School where he completed clinical training in Internal Medicine and Clinical Genetics (Brigham and Women’s Hospital). He performed his post-doctoral studies in the laboratory of Douglas Melton Ph.D. (Harvard University) where he studied β-cell regeneration. Justin obtained his M.D., Ph.D degrees from New York University Medical School where he was a graduate student in the laboratory of Daniel Rifkin, Ph.D. and studied the post-translational regulation of transforming growth factor-β (TGF-β).

Dr. Annes’ runs the Endocrine Genetics Clinic at Stanford Hospital that focuses on the care of patients and families with Endocrine Tumor Syndromes such as Multiple Endocrine Neoplasia and Hereditary Paraganglioma. His nonprofessional interests include tennis (All-American at Haverford College), Sci-Fi novels and Family.  

Academic Scientists

Neali A. Armstrong PhD

Neali did her Ph.D in Biochemistry and Molecular Biophysics at Columbia University with Eric Gouaux where she solved crystal structures of the AMPA receptor ligand-binding domain in complex with several ligands.  She received a Jane Coffin Childs post-doctoral fellowship to continue studying the structure-function relationships of the AMPA receptor using electrophysiological and biochemical techniques.  Currrently, Neali is working on a mouse model for pheochromocytoma to determine how the loss of a metabolic enzyme  leads to tumorigenesis.   

Basic Research Scientist

Rebecca C. Schugar, PhD

Rebecca completed her PhD in Molecular Cell Biology at Washington University in Saint Louis with Peter Crawford, MD, PhD; her work focused on understanding the role of myocardial ketone body oxidation under both physiological and pathological stresses. Rebecca continued her studies in metabolism during her post-doc at the Cleveland Clinic Lerner Research Institute with Mark Brown, PhD, where her work centered on a hepatic enzyme connecting microbial-derived metabolites to host metabolic health. In the Annes Lab, Rebecca will continue to work on underlying mechanisms driving obesity and diabetes using mouse models with tissue-specific knockout of a key metabolic enzyme. 

Visiting Endocrinology Clinical/Research Fellow

Myat Han Soe, M.D., M.S

Myat received his medical degree from University of Medicine Mandalay, Myanmar in 2007 with the highest academic distinctions in many basic science and clinical disciplines throughout his medical school years. After medical school, Myat pursued his graduate degree in Health Science at Western Illinois University and finished Internal Medicine Residency including Chief Residency at Prince George's Regional Hospital of University of Maryland Medical System in 2015. He then joined Internal Medicine Residency Program at University of Massachusetts Medical School - Baystate as faculty academic hospitalist. He also served as medical director for residency morning conference and case reports curriculum while pursuing fellowship in Medical Education. He was the recipient of Martin Broder Award - The Best Teacher of the Year for two consecutive years. In 2018, Myat left his academic career as clinical educator and started Endocrinology fellowship at University of California San Francisco to become a clinician scientist. His clinical and research interests are related to oncologic endocrinology, especially tumor biology and management of neuroendocrine neoplasia. He recently joined Annes lab and his current work is to identify prognostic molecular markers in Pheochromocytoma and Paraganglioma. 

Visiting Instructor

Haixia Xu MD PhD

Haixia completed clinical training in Internal Medicine in the Third Affiliated Hospital of Sun Yat-sen University (P.R.China). She performed her post-doctoral studies in Weil Cornell Medical College with Xiaojing Ma and Xiaoyu Hu. Currently, she is working on identifying the optimal agents for reversing hypoglycemia.

Post-Docs

Sooyeon Jenny Lee PhD

Sooyeon received her Ph.D. in Physiology at Pennsylvania State University where she studied the role of the zinc transporter ZnT2 in mammary gland development and functions during lactation in the laboratory of Shannon L. Kelleher. Sooyeon joined Annes lab in July 2016 to study the molecular connections between cellular metabolism, growth and function in beta-cells. 

James Preston Holt-Martyn PhD

James joined the Annes Lab / Medicinal Chemistry Knowledge Center at Stanford ChEM-H in the fall of 2018 as a postdoctoral fellow. His work focuses on the development of  small molecule stimulators of beta-cell replication as a therapy for diabetes. Prior to Stanford, James completed his B.S and M.S. in Medicinal Chemistry at the University of Leeds and was awarded a first class honours degree in 2012. In 2018, Dr. Holt-Martyn graduated from the University of Oxford with a D.Phil. under the supervision of Professors Christopher Schofield, Christopher Pugh and Professor Sir Peter Ratcliffe as a BHF-CRE Cardiovascular Medicinal Chemistry Scholar. His doctoral research consisted of drug design within the field of hypoxia. Dr. Holt-Martyn designed and developed small molecules to selectively target the Fe(II), 2-oxogluatarate (2OG) Hypoxia Inducible Factor-α (HIF-α) prolyl hydroxylases over other 2OG oxygenases for HIF stabilisation for chronic anaemia. In addition, Dr. Holt-Martyn collaborated with Dr. Geoff Higgins and Professor Christopher Schofield to design and develop a novel mitochondrial inhibitor to reduce the cellular consumption of Oxygen to enhance radiotherapy.

 

Graduate Students

Tim Horton

Tim came to the Annes lab in January 2016 as a graduate student in the Chemistry program and ChEM-H CBI pre-doctoral fellow. Tim graduated from Ouachita Baptist University (Arkansas) with a B.S. in Chemistry and Physics in 2014 where his research with Marty Perry utilized computational modeling to study chiral drug metabolism. He spent a summer at UC-Berkeley in the laboratory of John Kuriyan studying inhibition of spleen tyrosine kinase and ZAP-70. Tim is currently working toward designing and characterizing small molecules that stimulate beta-cell replication as a treatment for Type II Diabetes. Outside of lab, Tim enjoys hiking, watching basketball, and spending time with his wife.­­

Hannah Moeller

Hannah earned her BS in Neuroscience from UCLA were she worked in the labs of David Krantz and Nigel Maidment. Her research included a drug-repurposing project for Parkinson’s disease, which targeted the vesicular monoamine transporter, and an investigation into the effects of endogenous opioids on addictive behaviors. After UCLA, Hannah came to Stanford as a PhD student in the Chemical and Systems Biology department and joined the Annes lab in the summer of 2016.  She is currently working to identify genetic and chemical modulators of beta-cell function.­­

Undergraduate/Master Student

Benjamin Yeh

Ben earned his BS in Bioengineering from Stanford and is now a masters student in Computer Science with a focus on biocomputation. He joined the Annes lab in 2016 while an undergraduate and is currently using mass spectrometry imaging to study the distribution of metabolites in pancreas tissue. Ben also enjoys sand volleyball and playing cello in the Stanford Symphony Orchestra.

Lab Alumni

Raquel Freeman

raqfreeman@gmail.com

Claire M. Storey

cstorey@mednet.ucla.edu

Paul Andrew Allegretti

pallegretti@theravance.com

Yassan Abdolazimi

Guadalupe Navarro PhD

gnavarro016@gmail.com

Robert Nichols  PhD

Senior Scientist @ Revolution Medicines

Sharon Chen

Stanford Undergraduate

Hailey D. Blain

Bowdoin College Undergraduate