Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.
Minhas, P.S., Liu, L., Moon, P.K., Joshi, A.U., Dove, C., Mhatre, S., Contrepois, K., Wang, Q., Lee, B.A., Coronado, M., Bernstein, M., Snyder, M.P., Migaud, M., Majeti, R., Mochly-Rosen, D., Rabinowitz, J.D., and Andreasson, K.I., Nature Immunology (2019), 20:50-63. Epub 2018 Nov 26. ***Featured in “News and Views”, Nature Immunology,, March 2019.  ***Faculty 1000 recommended. 

Activation of neuronal PGE2 EP2 signaling worsens cerebral injury in a model of stroke.
Liu, Q., Liang, X., Wang, Q., Wilson, E., Lam, R.K., Wang, J., Kong, W., Tsai, C.A., Pan, T., Larkin, P.B., Shamloo, M., and Andreasson, K.I. , PNAS (2019), 116: 10019-10024.

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity.
Liu, Q., Johnson, E.M., Lam, R.K., Wang, Q., Ye, H.B., Wilson, E.N., Minhas, P.S., Liu, L., Swarovski, M.S., Wang, J., Mehta, S.S.,  Yang, X., Rabinowitz, Yang, S.S., J.D., Mueller, C., James, M.L.,  and Andreasson, K.I.,   Nature Immunology (2019) 20: 1023-1034, Epub 2019 Jul 1. ***Featured in “News and Views”, Nature Immunology, July 2019; ***Featured in Scientific American

Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptors.
Ohmura, T., Tian, Y., Sarich, N., Ke, Y., Meliton, A., Shah, A.S., Andreasson, K., Birukov, K.G., Birukova, A.A., Mol Biol Cell (2017), 28: 1622-1635

Prostaglandin E receptor-4 receptor mediates endothelial barrier-enhancing and anti-inflammatory effects of oxidized phospholipids.
Oskolkova, O., Gawlak, G., Tian, Y. Ke, Y., Sarich, N., Son, S., Andreasson, K., Bochkov, V.N., Birukova, A.A., Birukov, K.G., FASEB J., (2017) 31: 4187-4202.

Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.
Chang, J., Mancuso, M. R., Maier, C., Liang, X., Yuki, K., Yang, L., Kwong, J. W., Wang, J., Rao, V., Vallon, M., Kosinski, C., Zhang, J. J., Mah, A. T., Xu, L., Li, L., Gholamin, S., Reyes, T. F., Li, R., Kuhnert, F., Han, X., Yuan, J., Chiou, S., Brettman, A. D., Daly, L., Corney, D. C., Cheshier, S. H., Shortliffe, L. D., Wu, X., Snyder, M., Chan, P., Giffard, R. G., Chang, H. Y., Andreasson, K., Kuo, C. J. Nat Med 2017; 23 (4): 450-460. doi: 10.1038/nm.4309. Epub 2017 Mar 13.

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Woodling, N. S., Colas, D., Wang, Q., Minhas, P., Panchal, M., Liang, X., Mhatre, S. D., Brown, H., Ko, N., Zagol-Ikapitte, I., Van der Hart, M., Khroyan, T. V., Chuluun, B., Priyam, P. G., Milne, G. L., Rassoulpour, A., Boutaud, O., Manning-Bog, A. B., Heller, H. C., Andreasson, K. I. Brain 2016; 139: 2063-2081. doi: 10.1093/brain/aww117. Epub 2016 May 13.

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease. 
Mhatre, S. D., Tsai, C. A., Rubin, A. J., James, M. L., Andreasson, K. I. Trends in neurosciences. 2015 38 (10): 621-636. doi: 10.1016/j.tins.2015.08.006. 

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
Johansson, J. U., Woodling, N. S., Wang, Q., Panchal, M., Hang, X., Trueba-Saiz, A., Brown, H. D., Mhatre, S. D., Loui, T., Andreasson, K. I. J Clin Invest. 2015; 125 (1): 350-364. doi: 10.1172/JCI77487

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.
Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI. J Neurosci. 2014 Apr 23;34(17):5882-94. doi: 10.1523/JNEUROSCI.0410-14.2014.

Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI. J Neurosci. 2013 Oct 2;33(40):16016-32. doi: 10.1523/JNEUROSCI.2203-13.2013.

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.
Shi, J., Wang, Q., Johansson, J. U., Liang, X., Woodling, N. S., Priyam, P., Loui, T. M., Merchant, M., Breyer, R. M., Montine, T. J., Andreasson, K. Annals of Neurology 2012; 72 (5): 788-798.

Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of beta-Amyloid in T(H)1 and T(H)17 Versions of Experimental Autoimmune Encephalomyelitis.
Grant, J. L., Ghosn, E. E., Axtell, R. C., Herges, K., Kuipers, H. F., Woodling, N. S., Andreasson, K., Herzenberg, L. A., Herzenberg, L. A., Steinman, L. Sci Transl Med 2012; 4 (145)

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.
Liang X, Lin L, Woodling NS, Wang Q, Anacker C, Pan T, Merchant M, Andreasson K. J Clin Invest. 2011; 121 (11): 4362-71

Emerging roles of PGE2 receptors in models of neurological disease.
Andreasson K, Prostaglandins Other Lipid Mediat. 2010; 91 (3-4): 104-12

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity.
Shi J, Johansson J, Woodling NS, Wang Q, Montine TJ, Andreasson K. J Immunol. 2010; 184 (12): 7207-18

The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.
Liang X, Wang Q, Shi J, Lokteva L, Breyer RM, Montine TJ, Andreasson K. Ann Neurol. 2008; 64 (3): 304-14

Cyclooxygenase-dependent lipid-modification of brain proteins.
Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA. Brain Pathol. 2005; 15 (2): 139-42

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K. J Neurosci. 2005; 25 (44): 10180-7

PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis.
Bilak M, Wu L, Wang Q, Haughey N, Conant K, St Hillaire C, Andreasson K. Ann Neurol. 2004; 56 (2): 240-8

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.
McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K. J Neurosci. 2004; 24 (1): 257-68

Publication Highlights

New Method for Tackling Stroke Restrains an Overactive Immune System

TREM1 Blockade: Killing Two Birds with One Stone

TREM1-ors shake the brain and gut after stroke

NAD-biosynthetic pathways regulate innate immunity

Calming inflammation to prevent stroke damage

Scientists shrink stroke damage in mice by calming immune cells outside brain