Recent Peer-Reviewed Research Publications

2020 Publications

Hernandez JD, Yu M, Sibilano R, Tsai M, Galli SJ. Development of multiple features of antigen-induced asthma pathology in a new strain of mast cell deficient BALB/c-Kit(W-sh/W-sh) mice. Lab Invest. 2020 Apr;100(4):516-526.
Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson H, Leung DYM, Lack G. Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented? Allergy. Accepted March 28, 2020. In Press.
Kim JB, Prunicki M, Haddad F, Dant C, Sampath V, Patel R, Smith E, Akdis C, Balmes J, Snyder MP, Wu JC, Nadeau KC. Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution. J Am Heart Assoc. 2020 Mar 17;9(6):e014944.
Sindher S, Alkotob SS, Shojinaga MN, Brough HA, Bahnson T, S C, Lack G, Leung DYM, Nadeau KC. Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient. Allergy. 2020 Mar 16. [Epub ahead of print].
Hoh RA, Joshi SA, Lee JY, Martin BA, Varma S, Kwok S, Nielsen SCA, Nejad P, Haraguchi E, Dixit PS, Shutthanandan SV, Roskin KM, Zhang W, Tupa D, Bunning BJ, Manohar M, Tibshirani R, Fernandez-Becker NQ, Kambham N, West RB, Hamilton RG, Tsai M, Galli SJ, Chinthrajah RS, Nadeau KC, Boyd SD. Origins and clonal convergence of gastrointestinal IgE(+) B cells in human peanut allergy. Sci Immunol. 2020 Mar 6;5(45).
Balbino B, Herviou P, Godon O, Stackowicz J, Goff OR, Iannascoli B, Sterlin D, Brûlé S, Millot GA, Harris FM, Voronina VA, Nadeau KC, Macdonald LE, Murphy AJ, Bruhns P, Reber LL. The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors. J Clin Invest. 2020 Mar 2;130(3):1330-1335.
Tsai M, Mukai K, Chinthrajah RS, Nadeau KC, Galli SJ. Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE. J Allergy Clin Immunol. 2020 Mar;145(3):885-896.e6.
Galli SJ. Complexities in analyzing human basophil responses to autoantibodies to IgE or FcεRI. J Allergy Clin Immunol. 2019 Mar;143(3):932-934.
Prunicki MM, Dant CC, Cao S, Maecker H, Haddad F, Kim JB, Snyder M, Wu J, Nadeau K. Immunologic effects of forest fire exposure show increases in IL-1β and CRP. Allergy. 2020 Feb 28. [Epub ahead of print].
Neeland MR, Andorf S, Manohar M, Dunham D, Lyu SC, Dang TD, Peters RL, Perrett KP, Tang MLK, Saffery R, Koplin JJ, Nadeau KC. Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life. Nat Commun. 2020 Feb 27;11(1):1091
Niespodziana K, Borochova K, Pazderova P, Schlederer T, Astafyeva N, Baranovskaya T, Barbouche MR, Beltiukov E, Berger A, Borzova E, Bousquet J, Bumbacea RS, Bychkovskaya S, Caraballo L, Chung KF, Custovic A, Docena G, Eiwegger T, Evsegneeva I, Emelyanov A, Errhalt P, Fassakhov R, Fayzullina R, Fedenko E, Fomina D, Gao Z, Giavina-Bianchi P, Gotua M, Greber-Platzer S, Hedlin G, Ilina N, Ispayeva Z, Idzko M, Johnston SL, Kalayci Ö, Karaulov A, Karsonova A, Khaitov M, Kovzel E, Kowalski ML, Kudlay D, Levin M, Makarova S, Matricardi PM, Nadeau KC, Namazova-Baranova L, Naumova O, Nazarenko O, O Byrne PM, Osier F, Pampura AN, Panaitescu C, Papadopoulos NG, Park HS, Pawankar R, Pohl W, Renz H, Riabova K, Sampath V, Sekerel BE, Sibanda E, Siroux V, Sizyakina LP, Sun JL, Szepfalusi Z, Umanets T, Van Bever HPS, van Hage M, Vasileva M, von Mutius E, Wang JY, Wong GWK, Zaikov S, Zidarn M, Valenta R. Towards personalization of asthma treatment according to trigger factors. J Allergy Clin Immunol. 2020 Feb 17. [Epub ahead of print].
Warren CM, Jiang J, Gupta RS. Epidemiology and Burden of Food Allergy. Curr Allergy Asthma Rep. 2020 Feb 14;20(2):6.
Liu F, Singhal K, Matney R, Acharya S, Akdis CA, Nadeau KC, Chien AS, Leib RD. Enhancing Data Reliability in TOMAHAQ for Large-Scale Protein Quantification. Proteomics. 2020 Feb 7. [Epub ahead of print].
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC. Food Allergy from Infancy through Adulthood. JACI: In Practice. Accepted Feb 2020. In Press.
Galli SJ. The TWEAK/Fn14 axis in anaphylactic shock. J Allergy Clin Immunol. 2020 Feb;145(2):491-493.
Long A, Borro M, Sampath V, Chinthrajah RS. New Developments in Non-allergen-specific Therapy for the Treatment of Food Allergy. Curr Allergy Asthma Research. 2020 Jan 16;20(1):3.
Luce S, Chinthrajah S, Lyu SC, Nadeau K, Mascarell L. Th2A and Th17 cell frequencies and regulatory markers as follow-up biomarker candidates for successful multifood oral immunotherapy. Allergy. 2020 Jan 12. [Epub ahead of print].
DeKruyff RH, Zhang W, Nadeau, KC, Leung DYM, Wills-Karp M. Summary of the Keystone Symposium “Origins of Allergic Disease: Microbial, Epithelial and Immune Interactions”, March 24-27, Tahoe City, CA. J Allergy Clin Immunol. 2020 Jan 8. [Epub ahead of print].
El Abbas S, Radermecker C, Bai Q, Beguin C, Schyns J, Meunier M, Pirottin D, Desmet CJ, Meuwis MA, Art T, Louis E, Tam SY, Tsai M, Bureau F, Galli SJ, Marichal T. Epithelial RABGEF1 deficiency promotes intestinal inflammation by dysregulating intrinsic MYD88-dependent innate signaling. Mucosal Immunol. 2020 Jan;13(1):96-109.
Tsai M, Chinthrajah S, Nadeau KC. Legends of Allergy: Stephen J. Galli. Allergy. 2020 Jan;75(1):243-245.

2019 Publications

Breiteneder H, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O’Hehir R, O‘Mahony L, Pfaar O, Torres MJ, Wang DY, Zhang L, Akdis CA. Future trends in mechanisms and patient care in allergic diseases. Allergy. 2019 Dec;74(12):2293-2311.
Long A, Bunning B, Borro M, Sampath V, Nadeau, KC. The Future of omics for clinical practice. Ann Allergy Asthma Immunol. 2019 Dec;123(6):535-536.
Dhondalay GKR, Bunning B, Bauer RN, Barnathan ES, Maniscalco C, Baribaud F, Nadeau KC, Andorf S. Transcriptomic and methylomic features in asthmatic and non-asthmatic twins. Allergy. Nov 22, 2019. [Epub ahead of print].
Bunning BJ, Contrepois K, Lee-McMullen B, Dhondalay GKR, Zhang W, Tupa D, Raeber O, Desai M, Nadeau KC, Snyder MP, Andorf S. Global metabolic profiling to model biological processes of aging in twins. Aging Cell. 2019 Nov 19:e13073.
Sampath V, Sindher SB, Alvarez Pinzon AM, Nadeau KC. Can food allergy be cured? What are the future prospects? Allergy. 2019 Nov 16. [Epub ahead of print].
Chinthrajah S, Cao S, Liu C, Lyu SC, Sindher SB, Long A, Sampath V, Petroni D, Londei M, Nadeau KC. . Phase 2a randomized, placebo-controlled study of anti-IL-33 inpeanut allergy. JCI Insight. 2019 Nov 14;4(22).
Andorf S, Bunning B, Tupa D, Cao S, Long A, Borres MP, Galli SJ, Chinthrajah RS, Nadeau KC. Trends in egg specific immunoglobulin levels during natural tolerance and oral immunotherapy. Allergy. Accepted November 14, 2019. [Epub ahead of print].
Kivistö JE, Clarke A, Dery A, De Schryver S, Shand G, Huhtala H, Mäkelä MJ, Asai Y, Nadeau K, Harada L, Chan ES, Ben-Shoshan M. Genetic and environmental susceptibility to food allergy in a registry of twins. J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2916-2918.
Iliopoulou BP, Hsu K, Pérez-Cruz M, Tang SW, Pang WW, Erkers T, Kambham N, Freeman GJ, Dekruyff RH, Meyer EH. Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation. Blood Adv. 2019 Nov 12;3(21):3419-3431.
Eiwegger T, Anagnostou K, Arasi S, Bégin P, Ben-Shoshan M, Beyer K, Blumchen K, Brough H, Caubet JC, Chan ES, Chinthrajah S, Davis CM, Roches AD, Du Toit G, Elizur A, Galli SJ, Håland G, Hoffmann-Sommergruber K, Kim H, Leung DYM, Muraro A, Nurmatov UB, Pajno GB, Sindher S, Szepfalusi Z, Torres MJ, Upton J, Worm M, Nadeau K. ICER report for peanut OIT comes up short. Ann Allergy Asthma Immunol. 2019 Nov;123(5):430-432.
Eiwegger T, Anagnostou K, Arasi S, Bégin P, Ben-Shoshan M, Beyer K, Blumchen K, Brough H, Caubet JC, Chan ES, Chen M, Chinthrajah S, Davis CM, Roches AD, Du Toit G, Elizur A, Galli SJ, Håland G, Hoffmann-Sommergruber K, Kim H, Leung DYM, Long A, Muraro A, Nurmatov UB, Pajno GB, Sampath V, Saxena J, Sindher S, Upton J, Worm M, Nadeau K. Conflicting verdicts on peanut OIT from the ICER and FDA Advisory Committee; where do we go from here? J Allergy Clin Immunol. 2019 Nov 1. [Epub Ahead of Print].
Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nat Immunol. 2019 Nov;20(11):1435-1443.
Du Toit G, Elizur A, Nadeau KC. Cow's Milk and Vitamin D Supplementation in Infants-Timing Is Everything. JAMA Pediatr. 2019 Oct 21. [Epub ahead of Print].
Chinthrajah RS, Purington N, Andorf S, Long A, O'Laughlin KL, Lyu SC, Manohar M, Boyd SD, Tibshirani R, Maecker H, Plaut M, Mukai K, Tsai M, Desai M, Galli SJ, Nadeau KC. Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2019 Oct 19;394(10207):1437-1449.
Yadava K, Medina CO, Ishak H, Gurevich I, Kuipers H, Shamskhou EA, Koliesnik IO, Moon JJ, Weaver C, Nadeau KC, Bollyky PL. Natural Tr1-like cells do not confer long-term tolerogenic memory. Elife. 2019 Oct 11;8.
Prunicki M, Kelsey R, Lee J, Zhou X, Smith E, Haddad F, Wu J, Nadeau K. The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children. Allergy. Oct;74(10):1989-1991.
Che H, Zhang Y, Jiang S, Jin T, Lyu SC, Nadeau KC, McHugh T. Almond (Prunus dulcis) Allergen Pru du 8, the First Member of a New Family of Food Allergens. J Agric Food Chem. 2019 Aug 7;67(31):8626-8631.
Davis MM, Boyd SD. Recent progress in the analysis of αβT cell and B cellreceptor repertoires. Curr Opin Immunol. 2019 Jul 17;59:109-114.
Yu S, Leung KM, Kim HY, Umetsu SE, Xiao Y, Albacker LA, Lee HJ, Umetsu DT,Freeman GJ, DeKruyff RH. Blockade of Repulsive guidance molecule b (RGMb)inhibits allergen-induced airways disease. J Allergy Clin Immunol. 2019 Jul;144(1):94-108.e11.
Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC. Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes. Circ Res. 2019 Jun 21;125(1):90-103.
Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling Cardiovascular Risks of E-Cigarettes with Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 Jun 4;73(21):2722-2737.
Upton J, Montserrat A, Nadeau K. A perspective on the pediatric death from oral food challenge reported from the Allergy Vigilance Network. Allergy. 2019 Jun;74(6):1035-1036.
Howe LC, Leibowitz KA, Perry MA, Block W, Kaptchuk TJ , Nadeau KC, Alia J. Crum AJ. Changing Patient Mindsets About Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial. J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1550-1559.
Wheatley LM, Wood R, Nadeau K, Liu A, Zoratti E, Bacharier L, Brittain E, Calderon M, Casale T, Chipps B, Cox L, Creticos PS, Desai M, Dreborg S, Durham S, Gergen PJ, Gruchalla R, Nelson H, O'Hehir RE, Plaut M, Schwaninger JM, Tilles S, Vickery B, Wittenberg KM, Togias A. Mind the gaps: clinical trial concepts to address unanswered questions in aeroallergen immunotherapy. An NIAID/AHRQ Workshop. J Allergy Clin Immunol. 2019 May;143(5):1711-1726.
Yu W, Zhou X, Dunham D, Lyu S, Manohar M, Zhang W, Zhao F, Davis MM, Nadeau K. Allergen Specific CD8+ T cells in Peanut Allergic Individuals. J Allergy Clin Immunol. 2019 May;143(5):1948-1952.
Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA. Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells. J Allergy Clin Immunol. 2019 May;143(5):1892-1903.
Emeny RT, Korrick SA, Li Z, Nadeau K, Madan J, Jackson B, Baker E, Karagas MR. Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study. Environ Res. 2019 Apr;171:523-529.
Sampath V, Nadeau KC. Newly identified T cell subsets in mechanistic studies of food immunotherapy. J Clin Invest. 2019 Apr 1;129(4):1431-1440.
Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 Mar 12;321(10):946-955.
Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M. Report from the National Institute of Allergy and Infectious Diseases Workshop on "Atopic Dermatitis and the Atopic March: Mechanisms and Interventions". J Allergy Clin Immunol. 2019 Mar;143(3):894-913.
Suarez-Farinas M, Suprun M, Chang HL, Gimenez G, Grishina G, Getts R, Nadeau K, Wood RA, Sampson HA. Predicting development of "sustained unresponsiveness" to milk oral immunotherapy using epitope profiles. J Allergy Clin Immunol. 2019 Mar;143(3):1038-1046.
Galli SJ. Complexities in analyzing human basophil responses to autoantibodies to IgE or FcεRI. J Allergy Clin Immunol. 2019 Mar;143(3):932-934.
Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider L, Oettgen HC. IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies. Ann Allergy Asthma Immunol. 2019 Feb;122(2):213-215.
Nowak-Węgrzyn A, Wood RA, Nadeau KC, Pongracic JA, Henning AK, Lindblad RW, Beyer K, Sampson HA. Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy. J Allergy Clin Immunol. 2019 Feb;143(2):651-661.e9.
Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol. 2019 Feb;20(2):129-140.
Andorf S, Purington N, Kumar D, Long A, O'Laughlin K, Sicherer S, Sampson H, Cianferoni A, Whitehorn TB, Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Desai M, Galli SJ, Rael E, Assa’ad A, Chinthrajah S, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Nadeau K. A Phase 2 randomized controlled multisite study using omalizumab-facilitated rapid desensitization to test continued vs discontinued dosing in multifood allergic individuals. Lancet eClinicalMedicine. 2019. Jan 21. 2019 Jan; 7:27-48.
Che H, Zhang Y, Lyu SC, Nadeau KC, McHugh T. Identification of almond (Prunus dulcis) vicilin as a food allergen. J Agric Food Chem. 2019 Jan 9;67(1):425-432.
Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, Schleimer RP, Nadeau KC. Prevalence and Severity of Food Allergies Among US Adults. JAMA Netw Open. 2019 Jan 4;2(1):e185630.

2018 Publications

Croote D, Darmanis S, Nadeau KC, Quake SR. High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes. Science. 2018 Dec 14;362(6420):1306-1309.
Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang J, Davis MM, Nadeau KC. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018 Dec;142(6).
Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Andorf S, Tupa D, Kumar D, Woch MA, O'Laughlin KL, Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Nadeau KC, Chinthrajah RS. Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens. Front Immunol. 2018 Nov 27;9:2689.
PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018 Nov 22;379(21):1991-2001.
Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim KP, Bunning B, Doyle AD, Jacobsen EA, Boyd SD, Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Chinthrajah RS. Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy. Front Immunol. 2018 Nov 22;9:2624.
Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT. Differences in multiple immune parameters between Indian and U.S. infants. PLoS One. 2018 Nov 16;13(11):e0207297.
Yu M, Mukai K, Tsai M, Galli SJ. Thirdhand smoke component can exacerbate a mouse asthma model via mast cells. J Allergy Clin Immunol. 2018 Nov;142(5):1618-1627.e9.
Birrueta G, Tripple V, Pham J, Manohar M, James EA, Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V. Peanut-specific T cell responses in patients with different clinical reactivity. PLoS One. 2018 Oct 10;13(10):e0204620.
Sindher SB, Long A, Acharya S, Sampath V, Nadeau KC. The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. Clin Rev Allergy Immunol. 2018 Oct;55(2):190-204.
Purington N, Chinthrajah RS, Long A, Sindher S, Andorf S, O'Laughlin K, Woch MA, Scheiber AJ, Assa’ad A, Pongracic J, Spergel J, Tam J, Tilles S, Wang J, Galli SJ, Desai M, Nadeau KC. Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges. Frontiers in Immunology. 2018 Sep 21;9:2057.
Zhang W, Sindher S, Sampath V, Nadeau KC. Comparison of Sublingual Immunotherapy and Oral Immunotherapy in Peanut Allergy. Allergo J Int. 2018 September; 27(6):153-161.
Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee C, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 Jul 31;24(5):1377-1388.
Rice MB, Malea NM, Pinkerton KE, Schwartz J, Nadeau KC, Browner CM, Whitehouse S, Thurston GD. Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health: Where Science Meets Policy. Ann Am Thorac Soc. 2018 Jul;15(7):791-798.
Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC. Development of a Tool Predicting Severity of Allergic Reaction During Peanut Challenge. Ann Allergy Asthma Immunol. 2018 Jul;121(1):69-76.e2.
Chinthrajah RS, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC. High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. Ann Allergy Asthma Immunol. 2018 Jul;121(1):117-119.e1.
Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW. Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects. Front Immunol. 2018 Jun 25;9:1408.
Klein O, Roded A, Hirschberg K, Fukuda M, Galli SJ, Sagi-Eisenberg R. Imaging FITC-dextran as a Reporter for Regulated Exocytosis. J Vis Exp. 2018 Jun 20;(136).
Gaudenzio N, Marichal T, Galli SJ, Reber LL. Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity. Front Immunol. 2018 Jun 5;9:1275.
Zhang W, Lin C, Sampath V, Nadeau K. Impact of allergen immunotherapy in allergic asthma. Immunotherapy. 2018 Jun;10(7):579-593.
Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ. Isotype-Specific Agglutination- PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J Allergy Clin Immunol. 2018 May;141(5):1901-1904.e15.
Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O'Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A; EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018 Apr;73(4):799-815.
Sampath V, Sindher SB, Zhang W, Nadeau KC. New Treatment Directions in Food Allergy. Ann Allergy Asthma Immunol. 2018 Mar;120(3):254-262.
Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018 Mar;282(1):121-150.
Andorf S, Purington N, Block WM, Long AJ, Tupa D, Brittain E, Spergel AR, Desai M, Galli SJ, Nadeau KC, Chinthrajah RS. Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):85-94.
Prunicki M, Stell L, Dinakarpandian D, De Planell-Saguerd M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma. Clin Epigenetics. 2018 Jan 5;10:2.
Dhondalay GK, Rael E, Acharya, S, Zhang W, Sampath V, Galli SJ, Tibshirani, R, Boyd SD, Maecker, H, Nadeau KC, Andorf S. Food allergy and omics. J Allergy Clin Immunol. 2018 Jan;141:20-29.
Pellerin L, Jenks JA, Chinthrajah S, Dominguez T, Block W, Zhou X, Noshirvan A, Gregori S, Roncarolo MG, Nadeau KC, Bacchetta R. Peanut-specific Tr1 cells induced in vitro from allergic individuals are functionally impaired. J Allergy Clin Immunol. 2018 Jan;141(1):202-213.e8.
Galli SJ, Gaudenzio N. Human mast cells as antigen-presenting cells: when is this role important in vivo? J Allergy Clin Immunol. 2018 Jan;141(1):92-93.
Tam IYS, Ng CW, Lau HYA, Tam SY. Degradation of Monocyte Chemoattractant Protein-1 by Tryptase Co-Released in Immunoglobulin E-Dependent Activation of Primary Human Cultured Mast Cells. Int Arch Allergy Immunol. 2018;177(3):199-206.

2017 Publications

Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V,Chinthrajah RS, Nadeau KC. Feasibility of sustained response through long-term dosing in food allergy immunotherapy. Allergy Asthma Clin Immunol. 2017 Dec 21;13:52.
Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V, Chinthrajah RS, Nadeau KC. Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab. Allergy Asthma Clin Immunol. 2017 Dec 21;13:51.
Klein O, Roded A, Zur N, Azouz NP, Pasternak O, Hirschberg K, Hammel I, Roche PA, Yatsu A, Fukuda M, Galli SJ, Sagi-Eisenberg R. Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis. Sci Rep. 2017 Nov 10;7(1):15315.
Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial. JAMA. 2017 Nov 14;318(18):1798-1809.
Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC. Combining anti-IgE with oral immunotherapy. Pediatr Allergy Immunol. 2017 Nov;28(7):619-627.
Elizur A, Bollyky JB, Block WM. Elimination diet and the development of multiple tree-nut allergies. Pediatr Res. 2017 Oct;82(4):671-677
Frischmeyer-Guerrerio PA, Masilamani M, Gu W, Brittain E, Wood R, Kim J, Nadeau K, Jarvinen KM, Grishin A, Lindblad R, Sampson HA. Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy. J Allergy Clin Immunol. 2017 Oct;140(4):1043-1053.e8.
Andorf S, Borres MP, Block W, Tupa D, Bollyky JB, Sampath V, Elizur A, Lidholm, J, Jones JE, Galli SJ, Chinthrajah RS, Nadeau KC. Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children. J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1325-1334.e4.
Boyd SD, Hoh RA, Nadeau KC, Galli SJ. Immune monitoring for precision medicine in allergy and asthma. Curr Opin Immunol. 2017 Sep 6;48:82-91.
Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017 Aug;140(2):335-348.
Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017 Aug;72(8):1133-1147.
Chang HY, Nadeau KC. IL-4Rα Inhibitor for Atopic Disease. Cell. 2017 Jul 13;170(2):222.
Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev-Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC. Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. Allergy. 2017 Jul;72(7):1006-1021.
Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One. 2017 Jun 29;12(6):e0179606.
Park HK, Cheng KC, Tetteh AO, Hildemann LM, Nadeau KC. Effectiveness of Air Purifier on Health Outcomes and Indoor Particles in Homes of Children with Allergic Diseases in Fresno: A Pilot Study. J Asthma. 2017 May;54(4):341-346.
Galli SJ. Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma. N Engl J Med. 2017 May 18;376(20):1983-1984.
Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study. J Occup Environ Med. 2017 May;59(5):446-452.
Otani IM, Nadeau KC. Biologic Therapies for Immunoglobulin E-mediated Food allergy and Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2017 May;37(2):369-396.
Mukai K, Karasuyama H, Kabashima K, Kubo M, Galli SJ. Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4(+) T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect Immun. 2017 Apr 21;85(5).
Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 Apr;125(4):511-526.
Freeland DMH, Manohar M, Andorf S, Hobson BD, Zhang W, Nadeau KC. Oral immunotherapy for food allergy. Semin Immunol. 2017 Apr;30:36-44.
MacGinnitie AJ, Rachid R, Gragg H, Little SV, Lakin P, Cianferoni A, Heimall J, Makhija M, Robison R, Chinthrajah RS, Lee J, Lebovidge J, Dominguez T, Rooney C, Lewis MO, Koss J, Burke-Roberts E, Chin K, Logvinenko T, Pongracic JA, Umetsu DT, Spergel J, Nadeau KC, Schneider LC. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017 Mar;139(3):873-881.e8.
Ahuja SK, Manoharan MS, Harper NL, Jimenez F, Hobson BD, Martinez H, Ingale P, Liu YG, Carrillo A, Lou Z, Kellog DL, Ahuja SS, Rather CG, Esch RE, Ramirez DA, Clark RA, Nadeau K, Andrews CP, Jacobs RL, He W. Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. J Allergy Clin Immunol. 2017 Mar;139(3):844-854.
Mukai K, Gaudenzio N, Gupta S, Vivanco N, Bendall SC, Maecker HT, Chinthrajah RS, Tsai M, Nadeau KC, Galli SJ. Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Mukai K, Chinthrajah RS, Nadeau KC, Tsai M, Gaudenzio N, Galli SJ. A new fluorescent-avidin-based method for quantifying basophil activation in whole blood. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Balbino B, Sibilano R, Starkl P, Marichal T, Gaudenzio N, Karasuyama H, Bruhns P, Tsai M, Reber LL, Galli SJ. Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J Allergy Clin Immunol. 2017 Feb;139(2):584-596.e10.
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T. Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4. J Agric Food Chem. 2017 Jan 18;65(2):454-462.
Beutier H, Gillis CM, Iannascoli B, Godon O, England P, Sibilano R, Reber LL, Galli SJ, Cragg MS, Van Rooijen N, Mancardi DA, Bruhns P, Jönsson F. IgG subclasses determine pathways of anaphylaxis in mice. J Allergy Clin Immunol. 2017 Jan;139(1):269-280.e7.
Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2017 Jan;56(1):109-120.
Sampath V, Tupa D, Graham MT, Chatila TA, Spergel JM, Nadeau KC. Deciphering the black box of food allergy mechanisms. Ann Allergy Asthma Immunol. 2017 Jan;118(1):21-27.

2016 Publications

Sibilano R, Gaudenzio N, DeGorter MK, Reber LL, Hernandez JD, Starkl PM, Zurek OW, Tsai M, Zahner S, Montgomery SB, Roers A, Kronenberg M, Yu M, Galli SJ. A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016 Dec 16;7:13696.
Yu W, Freeland DM, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016 Dec;16(12):751-765.
Zhang Y, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, McHugh TH. Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. Food Research International. 2016 Dec;90:268-274.
Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2016 Nov 1;126(11).
Bunning BJ, DeKruyff RH, Nadeau KC. Epigenetic Changes During Food-Specific Immunotherapy. Curr Allergy Asthma Rep. 2016 Nov;16(12):87.
Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA. The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nat Commun. 2016 Oct 27;7:13198
Hussey Freeland DM, Fan-Minogue H, Spergel JM, Chatila TA, Nadeau KC. Advances in food allergy oral immunotherapy: toward tolerance. Curr Opin Immunol. 2016 Oct;42:119-123
Graham MT, Andorf S, Spergel JM, Chatila TA, Nadeau KC. Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. Curr Allergy Asthma Rep. 2016 Oct;16(10):75.
Mukai K, Tsai M, Starkl P, Marichal T, Galli SJ. IgE and mast cells in host defense against parasites and venoms. Semin Immunopathol. 2016 Sep;38(5):581-603.
Rael E. Allergen Immunotherapy . Prim Care. 2016 Sep;43(3):487-94.
Dhami S, Nurmatov U, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen L, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review. Clin Transl Allergy. 2016 Jul 5;6:24.
Ng E, Nadeau KC, Wang SX. Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection. Biosens Bioelectron. 2016 Jun 15;15;80:359-65.
Farzan SF, Li Z, Korrick SA, Spiegelman D, Enelow R, Nadeau K, Baker E, Karagas MR. Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort. Environ Health Perspect. 2016 Jun;124(6):840-7.
Zhang Y, Lee B, Du WX, Lyu SC, Nadeau KC, Grauke LJ, Zhang Y, Wang S, Fan Y, Yi J, McHugh TH. Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2. J Agric Food Chem. 2016 May 25;64(20):4146-51
Pennington LF, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham MT, Nadeau KC, Eggel A, Jardetzky TS. Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nat Commun. 2016 May 19;7:11610.
Galli SJ. Toward precision medicine and health: Opportunities and challenges in allergic diseases. J Allergy Clin Immunol. 2016 May;137(5):1289-300.
Wood RA, Kim JS, Lindblad R, Nadeau K, Henning AK, Dawson P, Plaut M, Sampson HA. A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. J Allergy Clin Immunol. 2016 Apr;137(4):1103-10.e1-11.
Chinthrajah RS, Hernandez JD, Boyd SD, Galli SJ, Nadeau KC. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol. 2016 Apr;137(4):984-97.
Ryan JF, Hovde R, Glanville J, Lyu S-C, Ji X, Gupta S, Tibshirani RJ, Jay DC, Boyd SD, Chinthrajah RS, Davis MM, Galli SJ, Maecker HT, Nadeau KC. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1286-95.
Bauer RN, Chinthrajah RS, Andorf S, Hobson B, Miller RL, Nadeau KC. T-Cell Immunophenotyping of Second-Hand Smoke-related Asthma. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S95.
Chang, A, Block W, Bollyky JB, Chinthrajah RS, Nadeau KC, Elizur A. Exploring Correlations Between Cross-Reactive Tree Nuts in Multiple Food Allergic Patients. J Allergy Clin Immunol. 2016 Feb;137(2):AB200.
Singh S, Kshirsagar RA , Dominguez TLR, Tupa D, Block W, Chinthrajah RS, Nadeau KC. Long-Term Follow-up of Oral Immunotherapy for Multiple Food Allergies. J Allergy Clin Immunol, 2016 Feb;137(2):AB132.
Elizur A, Bollyky JB, Block W, Nadeau KC. Different Triggers for the Diagnosis of Individual Food Allergies in Multiple Food Allergic Patients. J Allergy Clin Immunol, 2016 Feb;137(2):AB156.
Prunicki M, Zhou X, de Planell-Saguer M, Miller R, Nadeau KC. Identification of Tr1 Cells and Other CD4+ T Cell Subsets in Humans Using Mass Cytometry: A Tool for Understanding Asthma. J Allergy Clin Immuol, 2016 Feb;137(2):AB410.
Slatkin SC, Tupa D, Nadeau KC, Chinthrajah RS. Fraction of Exhaled Nitric Oxide (FeNO) and Abdominal Pain and/or Vomiting in Reaction to Oral Food Challenge. J Allergy Clin Immunol, 2016 Feb;137(2):AB135.
De Schryver S, Dery A, Clarke AE, Nadeau KC, Harada L, Greenwood C, Weatherall K, Daley D, Asai Y, Bamforth F, Ben-Shoshan M. START: Susceptibility to Food Allergies in a Registry of Twins. J Allergy Clin Immunol, 2016 Feb;137(2):AB152
Zhang Y, Du WX, Fan Y, Nadeau KC, McHugh TH. Prediction and Identification of Korean Pine (Pinus koraiensis) Vicilin As a Food. J Allergy Clin Immunol, 2016 Feb;137(2):AB267.
Noshirvan A, Petroni DH, Tsai M, Galli SJ, Chintrajah RS, Nadeau KC. Trends in Adverse Reactions Requiring Epinephrine in the Build-up Phase of Oral Immunotherapy. J Allergy Clin Immunol, 2016 Feb;137(2):AB131.
Galli SJ. The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis. Am J Pathol. 2016 Feb;186(2):212-24.
Ma J, Strub P, Lv N, Xiao L, Camargo CA Jr, Buist AS, Lavori PW, Wilson SR, Nadeau KC, Rosas LG. Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. Eur Respir J. 2016 Jan;47(1):122-32.
Hoh RA, Joshi SA, Liu Y, Wang C, Roskin KM, Lee JY, Pham T, Looney TJ, Jackson KJ, Dixit VP, King J, Lyu SC, Jenks J, Hamilton RG, Nadeau KC, Boyd SD. Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. J Allergy Clin Immunol. 2016 Jan;137(1):157-67.
Galli SJ, Starkl P, Marichal T, Tsai M. Mast cells and IgE in defense against venoms: Possible "good side" of allergy?Allergol Int. 2016 Jan;65(1):3-15.
Cheng K-C, Zheng D, Tetteh AO, Park H-K, Nadeau KC & Hildemann LM. Personal exposure to airborne particulate matter due to residential dryer lint cleaning. Building and Environment. 2016. 98:145-149.
Cheng K-C, Park H-K, Tetteh AO, Zheng D, Ouellette NT, Nadeau KC & Hildemann LM. Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California. Aerosol Science and Technology. 2016. 50(8):835-845.

2015 Publications

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma: An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72.
Chinthrajah RS, Tupa D, Prince BT, Block WM, Rosa JS, Singh AM, Nadeau K. Diagnosis of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1393-408.
Prince BT, Mandel MJ, Nadeau K, Singh AM. Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatr Clin North Am. 2015 Dec;62(6):1479-92.
Geifman N, Bollyky J, Bhattacharya S, Butte AJ. Opening clinical trial data:are the voluntary data-sharing portals enough? BMC Med. 2015 Nov 11;13:280.
Walter JE, Rosen LB, Csomos K, et al. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 2;125(11):4135-48.
Bégin P, Schulze J, Baron U, Olek S, Bauer RN, Passerini L, Baccheta R, Nadeau KC. Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region. Clin Transl Allergy. 2015 Oct 20;5:35.
Vercelli D, Galli SJ. Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment. Curr Opin Immunol. 2015 Oct;36:ix-xi.
Roskin KM, Simchoni N, Liu Y, Lee JY, Seo K, Hoh RA, Pham T, Park JH, Furman D, Dekker CL, Davis MM, James JA, Nadeau KC, Cunningham-Rundles C, Boyd SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Sci Transl Med. 2015 Aug 26;7(302):302ra135
Lambrecht BN, Galli SJ. SnapShot: Integrated Type 2 Immune Responses. Immunity. 2015 Aug 18; 43(2):408-408.
Quake C, Nadeau KC. The role of epigenetic mediation and the future of food allergy research. Semin Cell Dev Biol. 2015 Jul;43:125-30.
Sabounchi S, Bollyky J, Nadeau K. Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. Curr Allergy Asthma Rep. 2015 Jun;15(6):533.
Bégin P, Nadeau KC. Changes in peanut-specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol. 2015 Jun;135(6):1636-8.
Reber LL, Sibilano R, Mukai K, Galli SJ. Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol. 2015 May; 8(3):444-63.
Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol. 2015 Apr 1; S0091-6749(15)00185-2.
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: Applications for food allergy. J Allergy Clin Immunol. 2015 Feb;135(2):312-323.
Pajno GB, Nadeau KC, Passalacqua G, Caminiti L, Hobson B, Jay DC, Arasi S, Chiera F, Salzano G. The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook. Expert Rev Clin Immunol. 2015 Jan;11(1):141-54.
Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth B, Mann J, Pratt B, Balmes J, Hammond K, Eisen E, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy. 2015 Jan;45(1):238-48.

2014 Publications

Graham MT, Nadeau KC. Lessons learned from mice and man: mimicking human allergy through mouse models. Clin Immunol. 2014 Nov;155(1):1-16.
Sleiman P, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau KC, Bredenoord A, Furuta G, Spergel J, and Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nature Communications. 2014 Nov 19;5:5593. *Participated in enrolling patients, provided technical support and material support.
Arasi S, Klingbeil E, Dominguez T, and Nadeau KC. Two year long term data on Quality of Life in Multiple Food Allergy Oral Immunotherapy. Allergy, Asthma, and Clinical Immunology. 2014 Nov; 10:57
Jay D, Manohar M, and Nadeau KC. Immune Mechanisms of Sublingual Immunotherapy. Current Allergy and Asthma Reports. 2014 Nov;14(11):473.
Lv N, Xiao L, Camargo C, Wilson S, Buist S, Strub P, Nadeau K, and Ma J. Abdominal and General Adiposity and Level of Asthma Control in Adults with Uncontrolled Asthma. Annals of the American Thoracic Society. 2014 Oct;11(8):1218-24. *Participated in acquisition of data, technical support, material support, and analysis and interpretation of data.
Luskin AT, Chipps BE, Rasouliyan L, Miller DP, Haselkorn T, Dorenbaum A. Impact of asthma exacerbations and asthma triggers on asthma-related quality of life in patients with severe or difficult-to-treat asthma. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):544-52. [Epub 2014 Jul 3]
Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau KC, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 13. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Alexander ES, Martin LJ, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 1. *Participated in enrolling patients in the study and acquisition of data.
Sampson H, Aceves S, Bock A, James J, Jones S, Lang D, Nadeau KC, Nowak-Wegrzyn A, Oppenheimer J, Perry T, Randolph C, Sicherer S, Simon R, Vickery B, and Wood R. Food Allergy: A practice parameter update-2014. J. of Allergy and Clinical Immunology. 2014 Aug. E publication. *Participated in design of parameters, material support, and review of data.
Manohar M and Nadeau KC. The Potential of anti-IgE in Food Allergy Therapy. Current Treatment Options in Allergy. 2014 Jun 1;1(2):145-156
Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. J Expo Sci Environ Epidemiol. 2014 Jun 18. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
McKenzie RB, Berquist WE, Nadeau KC, Louie CY, Chen SF, Sibley RK, Glader BE, Wong WB, Hofmann LV, Esquivel CO, Cox KL. Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure. Pediatr Transplant. 2014 Jun 14. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Begin P, Chinthrajah RS, Nadeau KC. Oral immunotherapy for the treatment of food allergy. Hum Vaccin Immunother. 2014 Jun 5;10(8).
Begin P and Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy, Asthma, and Clinical Immunology. 2014 May 28;10 (1):27.
Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau KC. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014 May 12;10(1):25.
Jones PP, Nadeau KC. Introduction to the special issue on Stanford Immunology. Immunol Res. 2014 May;58(2-3):161-3.
Pellerin L, Jenks JA, Bégin P, Bacchetta R, Nadeau KC. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res. 2014 May;58(2-3):358-68.
Klingbeil EC, Hew KM, Nygaard UC, Nadeau KC. Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res. 2014 May;58(2-3):369-73.
Bégin P, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Tavassoli M, Hoyte E, O'Riordan G, Blakemore A, Seki S, Hamilton RG, Nadeau KC. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology. 2014 Feb 20;10(1):7.
Syed A, Garcia M, Kohli A, Maecker H, Tsai M, Galli S, and Nadeau KC. Peanut oral immunotherapy results in increased antigen-induced Treg function and hypomethylation of FOXP3. The Journal of Allergy and Clinical Immunology. 2014 Feb;133(2):500-10.
Kanai T, Jenks J, Seki S, Bacchetta R, and Nadeau KC. Identification of STAT5A and STAT5B Target Genes in Human T cells. PLoS One. 2014 Jan 30;9(1):e86790.
Bégin P, Winterroth LC, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Hoyte E, O'Riordan G, Seki S, Blakemore A, Woch M, Hamilton RG, Nadeau KC. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology. 2014 Jan 15;10(1):1.

2013 Publications

Liu, J, Zhang, L, Winterroth, L, Garcia, M, Weiman, S, Wong, J, Sunwoo, J, and Nadeau, KC. Epigenetically-mediated pathogenic effects of phenanthrene on regulatory T cells. J Toxicol. 2013; 967-981.
Reber LL, Marichal T, Mukai K, Kita Y, Tokuoka SM, Roers A, Hartmann K, Karasuyama H, Nadeau KC, Tsai M, Galli SJ. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol. 2013 Oct;132(4):881-8. *Participated in obtaining funding, analysis and interpretation of data.
Syed A, Kohli A, and Nadeau KC. Food allergy diagnosis and therapy: where are we now? Immunotherapy. 2013 Sep; 5(9):931-44.
Chen R, Giliani S, Lanzi G, Mias GI, Lonardi S, Dobbs K, Manis J, Im H, Gallagher JE, Phanstiel DH, Euskirchen G, Lacroute P, Bettinger K, Moratto D, Weinacht K, Montin D, Gallo E, Mangili G, Porta F, Notarangelo LD, Pedretti S, Al-Herz W, Alfahdli W, Comeau AM, Traister RS, Pai SY, Carella G, Facchetti F, Nadeau KC, Snyder M, Notarangelo LD. Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. J Allergy Clin Immunol. 2013 Sep;132(3):656-664. *Participated in acquisition of data, and analysis and interpretation of data.
Syed, A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air Pollution and Epigenetics. Journal of Environmental Protection. 2013 Aug; 4:8A, 114-122.
Jenks JA, Seki S, Kanai T, Huang J, Morgan AA, Scalco RC, Nath R, Bucayu R, Wit JM, Al-Herz W, Ramadan D, Jorge AA, Bacchetta R, Hwa V, Rosenfeld R, Nadeau KC. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013 Aug;148(2):227-36.
Dominguez TL, Bégin P, Nadeau KC. The use of epinephrine in acute allergic reaction to food. Pediatric Annals. 2013 Jul;42(7):293-5.
Bégin P, Nadeau KC. Diagnosis of food allergy. Pediatr Ann. 2013 Jun 1;42(6):102-9.
Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT, Nadeau KC. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. Jun 2013;162(1):89-93
Ma J, Strub P, Lavori PW, Buist AS, Camargo CA Jr, Nadeau KC, Wilson SR, Xiao L. DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma. Contemporary Clinical Trials. 2013 May 3. *Participated in acquisition of data, analysis and interpretation of data, technical, and material support.
Le-Carlson M, Seki S, Abarbanel D, Quiros A, Cox K, and Nadeau KC. Markers of antigen presentation and activation on eosinophils and T-cells in the esophageal tissue of patients with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):257-62.
Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL. Immunomodulatory Effect of Vancomycin on Treg in Pediatric Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. J Clin Immunol. 2013 Feb;33(2):397-406. *Participated in acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of the manuscript for important intellectual content, technical support, material support, and statistical analysis.

2012 Publications

Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, and Nadeau KC. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7(11): p. 487-496.
Kanai T, Jenks J, Nadeau KC. The STAT5b pathway defect and Autoimmunity. Frontiers in Immunology. 2012; 3:234.
Kohli, A, Garcia, M, Miller, R, Maher, C, Humblet, O, Hammond, K, and Nadeau, KC. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. J. of Clinical Epigenetics. 2012 Sep 25;4(1):17. 2012.
Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012 Jul;130(1):215-224. (Recommended by Faculty 1000)
Yu GP, Weldon B, Neale-May S, Nadeau KC. The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial. Int Arch Allergy Immunol. 2012 Jun 1;159(2):179-182.
Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012 Jun;32(3):565-73.
Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC (co-senior author), Umetsu DT. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 2012 May;5(3):267-76.
Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr;19(2):284-8. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Recher M, Burns S, de la Fuente MA, Volpi S, Dahlberg C, Walter J, Moffitt K, Matthew D, Honke N, Lang, P, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau KC, Bouma G, Delmonte O, Frugoni F, Fomin A, Buchbinder D, Lundequist E-M, Massaad MJ, Tsokos G, Hartwig J, Manis J, Terhorst C, Geha R, Snapper S, Lang K, Malley R, Westerberg L, Thrasher A, Notarangelo L. B-cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. *Participated in enrolling patients in the study, and analysis and interpretation of data.
Pedroza L, Kumar V, Mace E, Nadeau KC, Perez E, Ruuskanen O, Orange J. AIRE contributes to Dectin-1-induced TNF-a production 1 and complexes with CARD9, Syk, and Dectin-1. J Allergy Clin Immunol. 2012 Feb;129(2):464-72. *Participated in enrolling patients in the study and analysis and interpretation of data.
Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT. Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33.

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